Postdoctoral Research Associate, Moreno Lab

About the Role

A Postdoctoral Research Associate position is available in the laboratory of Dr. Salvador Almagro-Moreno. The lab investigates the emergence and evolution of bacterial pathogens, focusing on molecular strategies for host colonization, virulence regulation, and dispersal. Research interests include pathogenic members of the family Vibrionaceae, with an emphasis on Vibrio cholerae and Vibrio vulnificus. The goal is to forecast emergent virulent strains, predict outbreak sources, and identify potential drug targets. The project aims to map how microbial toxins and protein complexes exist in native cellular environments using molecular microbiology, proteomics, and structural biology to reveal principles of macromolecular organization.

Key Responsibilities

• Lead research projects at the interface of molecular microbiology, host-pathogen interactions, and structural biology.
• Design and execute experiments.
• Analyze large-scale proteomic data and interpret results.
• Lead projects that integrate multiple scientific disciplines.
• Contribute to the development of novel projects and proposals.
• Mentor junior scientists.

Requirements & Tech Stack

• Strong publication record.
• Exceptional communication and organizational skills.
• Willingness to work in a team atmosphere.
• Excellent multitasking abilities.
• Independent thinking.
• Experience with molecular biology, mass spectrometry-based proteomics, or chemical probe development.
• Prior experience with protein complex analysis, crosslinking chemistry, or integrative modeling is advantageous but not required.
• Demonstrated record of scientific productivity, critical thinking, and collaborative research.

Skills and Knowledge

• Strong background in molecular biology, microbiology, or structural biology.
• Extensive experience with bacteriology and advanced molecular microbiology techniques.
• Demonstrated ability to design and execute experiments independently and to critically analyze data.
• Excellent written and verbal communication skills for contributing to manuscripts, presentations, and collaborative discussions.
• Commitment to scientific rigor, integrity, and teamwork in a multidisciplinary environment.

Preferred Skills and Knowledge

• Experience in mass spectrometry-based proteomics, crosslinking chemistry, or structural methods such as cryo-EM or integrative modeling.
• Familiarity with computational tools for protein structure analysis, molecular modeling, or large-scale data interpretation.
• Prior exposure to cell biology or in situ biochemical methods.
• Ability to mentor junior researchers and contribute to collaborative, multi-lab projects.
• Enthusiasm for learning new experimental and computational approaches.

Qualifications

• Ph.D. in Microbiology, Molecular Biology, Biochemistry, Structural Biology, or a related discipline.

About the Lab and St. Jude

The Moreno lab offers an intellectually stimulating and inclusive environment. The research program aligns with the "One Health" strategy and focuses on the interface between molecular microbiology, host-pathogen interactions, and microbial ecology, utilizing modern computational methods and evolutionary theory. St. Jude Children's Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood, known for its collaborative and multidisciplinary environment.

Postdoctoral Trainee Benefits

• Access to shared resources and facilities led by expert scientists.
• Customized professional and career growth programs, including grant writing workshops, individual development plans, teaching and mentoring opportunities, non-research career advancement programs, and a professional development allowance.
• Competitive salary starting at $72,500 a year, comprehensive benefits, and generous relocation assistance.
• A vibrant postdoc community that supports a well-balanced life.