Process Development Intern
StructaLink Group
Boston, MAFresher1h agovia LinkedIn
About the Role
- Temporary role with a third-party agency partner.
- 6-month experiential training program.
- Program Dates: January – July 2027.
- Full-time, paid co-op.
- Compensation: $30.00 – $50.00 USD/hour.
Key Responsibilities
- Support product development, manufacturing, and laboratory research.
- Contribute to a high-impact cryopreservation process development project for Type 1 Diabetes (T1D) drug product.
- Establish a cryo-microscopy workflow to evaluate CPA diffusion into islets and characterize islet responses across different cryoprotective formulations and cryopreservation conditions.
- Integrate experimental imaging data with computational modeling to characterize CPA diffusion kinetics, inform formulation development, and identify opportunities to optimize key cryopreservation parameters.
- Establish a standardized cryo-microscopy workflow for real-time imaging of stem cell-derived islets during CPA loading, unloading, and controlled freeze/thaw cycles.
- Design and execute cryopreservation studies using selected CPA formulations and loading/unloading strategies.
- Develop an initial computational modeling framework that complements experimental cryo-microscopy data.
- Model the correlation between CPA diffusion kinetics, islet size and morphology, and cryopreservation process parameters.
- Integrate experimental and computational results to characterize CPA diffusion kinetics and islet response across formulations and process conditions.
Requirements & Tech Stack
- Mammalian cell culture
- Aseptic technique
- Routine cell culture handling
- Media preparation
- Sample preparation
- Cell freezing and thawing
- Cell microscopy (sample preparation, cell staining, image acquisition, image-based evaluation)
- Computational modeling approaches (molecular dynamics, diffusion kinetics, or cryopreservation processes)
Qualifications
- Currently pursuing a graduate degree (PhD and Master’s are preferred); or undergraduate degree in:
- Cell Biology
- Molecular Biology
- Biochemistry
- Biotechnology
- Biomedical Engineering
- Bioengineering
- Chemical or Biochemical Engineering
- Pharmaceutical Sciences
- Computational Biology
- Or a related scientific discipline.
- Experience with stem cells or stem cell-derived products is preferred.
- Experience with cell aggregates, spheroids, organoids, or other three-dimensional cell systems is a plus.
- Experience with cryo-microscopy is a plus.
- Strong analytical, problem-solving, and organizational skills.
- Ability to independently troubleshoot experimental challenges, manage priorities, and maintain accurate documentation and attention to detail.
- Highly motivated and collaborative team player with strong communication skills, intellectual curiosity, and a desire to learn new techniques.
- Legal authorization to work in the United States, now and in the future.
- Must be enrolled in an advanced degree program if graduating before June 2027.