Physician Assistant

About the Role

SequenceMD is seeking a full-time Physician Assistant (PA-C) to join our Adult Ehlers-Danlos syndrome (EDS) and hereditary connective tissue disorders clinic in the Denver Metro Area, Colorado. This role offers the opportunity to develop specialized expertise in a complex and evolving area of medicine.

Key Responsibilities

• Conduct comprehensive new-patient evaluations and follow-up visits for patients with suspected or confirmed EDS and other hereditary connective tissue disorders.
• Obtain detailed medical, surgical, and family histories and review relevant medical records, prior evaluations, imaging, laboratory results, and genetic testing.
• Perform focused and comprehensive physical examinations, including assessment of joint hypermobility and other relevant clinical features.
• Apply established diagnostic criteria for hEDS and hypermobility spectrum disorders, recognizing when findings may suggest an alternative or additional diagnosis.
• Evaluate patients for features suggestive of other EDS subtypes, hereditary connective tissue disorders, and related genetic conditions.
• Develop individualized assessment and management plans based on clinical findings, diagnostic results, and current evidence.
• Provide clear patient education regarding diagnostic impressions, testing recommendations, results, and appropriate next steps.
• Provide clear and comprehensive clinical notes for each patient’s extended care team.
• Collaborate with medical geneticists and genetic counselors regarding test selection, diagnostic strategy, and complex clinical presentations.
• Document clinical reasoning and communicate findings in a manner that supports continuity of care and appropriate follow-up.
• Work closely with medical geneticists, genetic counselors, and other clinical team members to coordinate patient evaluations and diagnostic plans.
• Participate in case discussions involving complex presentations, suspected hereditary disorders, and challenging diagnostic questions.
• Support coordinated care for patients whose evaluations identify genetic findings requiring additional counseling, surveillance, or specialty management.
• Maintain clear, timely clinical documentation and communicate recommendations to patients and referring providers.
• Contribute to the continued development and improvement of SequenceMD's EDS and hereditary connective tissue disorders program.
• Stay current with evolving diagnostic criteria, clinical guidelines, genetic testing capabilities, and research relevant to connective tissue disorders.
• Identify opportunities to improve patient education, clinical workflows, diagnostic consistency, and overall patient experience.
• Participate in the development of clinical resources and processes that support high-quality, consistent care.

Requirements & Tech Stack

• Current Physician Assistant certification (PA-C).
• Active Colorado PA license or eligibility for Colorado licensure.
• Strong clinical assessment, documentation, and patient communication skills.
• Commitment to evidence-based, patient-centered care.
• Ability to work collaboratively within a multidisciplinary clinical team.
• Willingness to work full-time in person in the Denver metro area.
• Preferred: Two or more years of clinical experience in primary care, internal medicine, genetics, rheumatology, cardiology, or another relevant specialty.
• Preferred: Experience evaluating patients with EDS, hypermobility spectrum disorders, or other hereditary connective tissue disorders.
• Preferred: Familiarity with genetic testing, genetic test reports, and the interpretation of clinical findings in the context of inherited disease.
• Preferred: Experience managing medically complex patients or working in a specialty clinic.

Qualifications

• Thoughtful, curious clinician who enjoys working through complex medical presentations.
• Understands the complexities of patients with suspected connective tissue disorders.
• Comfortable managing diagnostic uncertainty.
• Capable of communicating complex information in understandable terms.
• Willing to collaborate with other clinicians.
• Interested in developing specialized knowledge in hereditary connective tissue disorders.
• Enjoys complex clinical evaluations and evidence-based diagnostic reasoning.
• Approaches patients with empathy, professionalism, and an open mind.
• Can balance validating a patient's symptoms with maintaining appropriate diagnostic rigor.
• Comfortable explaining uncertain, negative, or unexpected findings.
• Values collaboration and is receptive to consultation and feedback.
• Takes initiative, communicates effectively, and contributes ideas for improving clinical care.
• Interested in growing expertise in a specialized area of medicine.
• New graduates with strong clinical reasoning, curiosity, professionalism, and a willingness to learn are encouraged to apply.