Research Associate in Department of Physiology

About the Role

The Department of Physiology at the Perelman School of Medicine at the University of Pennsylvania is seeking candidates for a Research Associate position within the Academic Support Staff. This appointment is initially for one (1) year, with continuation and renewal based on satisfactory performance and funding availability (limited to three (3) years).

Key Responsibilities

• Conducting independent and collaborative research in structural proteomics, chemical biology, and mitochondrial biology.
• Developing and implementing mass spectrometry-based workflows, including chemical crosslinking mass spectrometry (XL-MS), quantitative proteomics, and protein interaction mapping.
• Operating and maintaining advanced LC-MS/MS instrumentation.
• Analyzing complex proteomics datasets.
• Mentoring students and trainees.
• Contributing to manuscript preparation, grant writing, and collaborative research projects.
• Establishing and leading new structural proteomics and crosslinking mass spectrometry capabilities.
• Developing independent research projects at the interface of proteomics, structural biology, neuroscience, and reproductive biology.
• Collaborating with investigators across relevant research communities.

Requirements & Tech Stack

• Expertise in mass spectrometry-based proteomics.
• Experience with LC-MS/MS instrumentation.
• Experience with experimental design for proteomics.
• Experience with proteomics data analysis.
• Strong expertise in protein biochemistry.
• Strong expertise in molecular biology.
• Strong expertise in quantitative proteomics approaches.
• Demonstrated experience designing and executing independent research projects.
• Experience working effectively within collaborative multidisciplinary teams.
• Experience with Orbitrap-based mass spectrometry platforms.
• Experience with quantitative proteomics workflows.
• Experience with advanced proteomics software tools.

Qualifications

• Ph.D. or M.D./Ph.D. degree.
• Strong record of original peer-reviewed publications.
• Scientific leadership skills.
• Communication skills.
• Interpersonal skills.

Preferred qualifications include expertise in chemical crosslinking mass spectrometry (XL-MS), structural proteomics, protein interaction mapping, chemical biology, development of novel analytical methodologies, and computational analysis of proteomics datasets. Experience with mitochondrial biology, neuroscience, reproductive biology, cryo-EM, or integrative structural biology is desirable but not required.