Scientist I, Oncology

About the Role

Generate:Biomedicines is seeking a Scientist I with expertise in cancer biology to support the discovery and development of protein-based oncology therapeutics. This is a laboratory-focused role requiring scientific judgment, rigorous documentation, and collaboration. The core focus will be oncology, with opportunities to expand drug discovery and development experience across other therapeutic areas.

Key Responsibilities

• Establish, maintain, and characterize cancer cell lines, tumor organoids, and primary cells, including cells from primary human tumor samples.
• Generate and validate engineered cell lines using transfection, transduction, and CRISPR-based editing.
• Design, execute, and troubleshoot assays for cell viability, proliferation, cytotoxicity, target binding, and receptor or antibody internalization, including tumor and immune cell co-cultures.
• Apply flow cytometry, live-cell imaging, plate-based assays, and immunoassays such as ELISA, AlphaLISA, and Meso Scale Discovery (MSD).
• Utilize molecular biology and biochemistry techniques to characterize therapeutic activity and mechanism of action.
• Analyze, interpret, and present experimental findings, recommending next steps for project decisions and pipeline progression.
• Collaborate with cross-functional partners in Automation, Computational Sciences, Protein Sciences, and High-Throughput Screening.
• Maintain complete and accurate experimental records.
• Stay current with advances in oncology, immuno-oncology, and biologics research.

Requirements & Tech Stack

• Ph.D. in cancer biology, cell biology, immunology, immuno-oncology, or a related field; OR Master's degree with six years of relevant experience; OR Bachelor's degree with eight years of relevant experience; OR eleven years of relevant experience.
• Strong foundation in cancer biology.
• Hands-on mammalian cell culture expertise, including work with cancer cell lines and primary cells.
• Hands-on experience with in vivo tumor models (xenograft, PDX, syngeneic), including assessment of tumor growth, treatment response, and pharmacodynamic biomarkers.
• Experience with cell line engineering.
• Proficiency in standard molecular biology and biochemistry techniques, such as cloning, PCR/RT-qPCR, and Western blotting.
• Experience developing and troubleshooting quantitative cell-based assays (cytotoxicity, viability, internalization).
• Proficiency in flow cytometry.
• Experience measuring proteins or cytokines using platforms such as ELISA, AlphaLISA, or MSD.
• Ability to independently plan experiments, select appropriate controls, analyze and interpret quantitative data, and recommend follow-up studies.
• Experience communicating scientific findings and collaborating within a multidisciplinary project team.

Preferred Qualifications

• Experience with tumor organoids, primary human tumor samples, or other patient-derived ex vivo models.
• Experience characterizing antibodies, multispecific proteins, or antibody conjugates in oncology.
• Experience with tumor and immune cell co-cultures, high-content or live-cell imaging, high-throughput screening, or machine learning-enabled drug discovery.

What Will Help You Thrive

• Scientific curiosity and rigor.
• Ability to solve moderately complex experimental problems with sound judgment.
• Clear written and verbal communication.
• Collaborative and flexible approach in a fast-paced environment.