Junior/Assistant Specialist in the Sampognaro Lab

University of California, San Francisco

The UCSF Department of Neurology is dedicated to advancing the understanding and treatment of neurological disorders, with a focus on groundbreaking research in the Neuromuscular Division. This role contributes to driving fundamental advances in neuromuscular disease through scientific investigation, elucidating disease mechanisms, developing diagnostic tools, and pioneering therapeutic strategies.

Job Summary

Assist with ongoing research projects within the Sampognaro Laboratory at UCSF, focusing on the role of lysosomal proteases and the autophagy-lysosome system in the pathogenesis of neurodegeneration, specifically in relation to ALS, frontotemporal dementia, Parkinson’s disease, and Alzheimer’s disease. This involves assisting in data generation for projects using cell culture of iPSCs and iPSC-derived neurons, biochemical techniques (Western blot/Silver stain), and confocal microscopy.

Key Responsibilities

• Basic lab procedures including Western blotting, cell culture, and immunocytochemistry.
• Microscopic imaging quantification and analysis.
• Data preparation.
• Maintain organized and accurate records/lab notebooks.
• Utilize computerized databases.
• Administrative tasks including assisting with lab ordering and lab organization.

Requirements & Tech Stack

• Junior Specialist: A bachelor’s degree in a related science or field, or at least four years of research experience.
• Assistant Specialist: Master’s degree in a related science, or bachelor’s degree with three or more years of research experience.
• Knowledge of or experience with basic techniques or methods required by the position.
• Working knowledge of lab equipment, including balances, pH meters.
• Candidates must meet the required qualifications at the time of appointment.
• Candidate’s CV or cover letter must state qualifications (or if pending) upon submission.

Preferred Qualifications

• Experience with Western blotting, including blot imaging and quantification.
• Experience in cell culture techniques.
• Knowledge of neuroanatomy.
• Knowledge of quantitative microscopy and imaging analysis.
• Statistical analysis experience.
• Coding experience is a plus.

Documentation Requirements

• Curriculum Vitae (CV) must clearly list current and/or pending qualifications.
• Cover Letter.
• 3 required references (contact information only).

Salary estimate: $57,000-$73,200