Scientist I, Neuromodulation Anatomy

About the Role

The Allen Institute accelerates science for a healthier world through large-scale research designed to answer complex biological questions. We generate foundational knowledge, tools, and data to understand how our brain, cells, and immune system work, sharing our work openly to drive discovery and improve human health.

The Neural Dynamics accelerator aims to understand how the brain generates flexible behavior by uncovering the algorithms—implemented by dynamics in brain-wide neural circuits—that allow animals to build internal models, process information, and choose actions.

We are seeking an exceptional scientist to join the Neuromodulation team to comprehensively map the structural organization of neuromodulatory systems in the mouse brain. Neuromodulators (e.g., norepinephrine, serotonin, dopamine, acetylcholine) are released by small neuron populations but exert widespread effects. Understanding the structural, molecular, and functional relationships among diverse neuromodulatory neurons is critical. This project integrates transcriptomic, morphological, and connectivity datasets to uncover organizational principles of neuromodulatory systems.

Key Responsibilities

• Help lead a research project to establish foundational knowledge of mammalian neuromodulatory cell types.
• Develop and devise conceptual and quantitative frameworks for understanding how neuronal properties across modalities relate to cell type identity and function.
• Conduct in-depth analyses and modeling of neuronal morphology using single neuron reconstruction data.
• Develop and apply methods to integrate transcriptomic, morphological, and connectivity data.
• Collaborate closely with experimentalists and computational scientists to advance shared research goals.
• Communicate project progress frequently and present findings to internal stakeholders and the broader scientific community.
• Help draft reports and manuscripts.

Requirements & Tech Stack

• PhD in Genomics, Neuroscience, Applied Mathematics, Electrical Engineering, Physics, or a related field; or equivalent combination of degree and experience.
• High proficiency in one or more high-level programming languages (e.g., Python, R).
• Strong grounding in mathematical and statistical methods.
• Deep familiarity with agentic workflows for data analysis.

Qualifications

• 0-5 years of postdoctoral research experience.
• Strong interest in neural circuits, cell types, and neuromodulation.
• Experience with cellular, systems, computational neuroscience.
• Ability to work independently and within a collaborative, multi-disciplinary environment to meet ambitious project timelines.
• Strong oral and written communication and organizational skills.
• Strong publication record appropriate to career stage.

This role offers relocation assistance and potential work visa sponsorship.