Research Associate I, Imaging

About the Role

The Allen Institute is seeking a Research Associate I to join an interdisciplinary team focused on spatial transcriptomics within the Brain Science accelerator. The team's goal is to produce high-quality in situ hybridization data to characterize brain cell types. This role involves executing laboratory tasks and experiments in a high-throughput environment, adhering to Standard Operating Procedures (SOPs). The position requires good judgment and problem-solving skills for process development, troubleshooting, and operating complex laboratory instrumentation. A well-organized candidate with a curiosity for scientific questions and a commitment to producing high-quality data in a timely manner is sought.

Key Responsibilities

• Operate fluorescence imaging microscopes.
• Handle mouse and human tissue.
• Perform multiple histological staining processes (Nissl, IHC, Biocytin, ISH).
• Prepare and assemble custom slides and imaging chambers.
• Operate MERSCOPE, Xenium, and other imaging equipment.
• Compile, process, and analyze data; evaluate and communicate research results.
• Evaluate, calibrate, and troubleshoot experiment quality and instrument functionality.
• Contribute to a scientifically rigorous, cohesive, and efficient team environment.
• Maintain accurate laboratory documentation using established methods, including Microsoft Office, Custom Laboratory Information Management System (LIMS), and other packages.
• Follow Standard Operating Procedures, good laboratory practices, and comply with all regulatory requirements.
• Other duties as assigned.

Requirements & Tech Stack

• Bachelor’s degree in a life science or related field.
• Basic knowledge of neuroscience and cell biology.
• Exceptional manual dexterity and attention to detail.
• Strong scientific communication skills (written and oral).
• 0-2 years experience working in a laboratory setting.
• Laboratory experience with cell or molecular biology.
• Hands-on experience working with microscopes.
• Strong computer skills, knowledge of databases, and reading/running scripts.
• Understanding of custom imaging software programs.

Work Environment

• Laboratory environment, including potential exposure to lasers and biohazards.
• Occasional exposure to safety hazards, noises, temperature changes, chemicals, and other hazardous materials and machinery.
• Exposure to Class IV lasers.

Physical Demands

• Stooping, bending, crouching.
• Reaching, or climbing ladders.
• Ability to resolve red/green colors.
• Fine motor movements in fingers/hands for operating computers and lab equipment.

Additional Information

• This role is currently onsite.
• Occasional weekend hours may be required.
• This opportunity does not sponsor work visas.
• This opportunity may offer relocation assistance.