Scientist I, Protein Biology

About the Team

The antibody team is involved in engineering and development of antibodies, with a deep focus on reagent quality and specificity. Core activities include design, development, purification, conjugation, and testing of antibodies in a variety of immunoassay applications using pioneering tools and technologies. The program's goal is advanced product development and creation of product-specific information for research use.

About the Role

To be an integral part of an antibody development team with a focus on performance and specificity using innovative molecular, protein, biochemical, and cell biology methods.

Key Responsibilities

• Meticulous experimental planning and execution to meet program goals.
• Timely record keeping of results into data sheets and laboratory notebooks.
• Regular mining of literature and keeping up to date with developments in antibody development.
• Compilation and presentation of data in written and oral formats.
• Active participation in team meetings.
• Attention to detail and adherence to schedules.

Requirements & Tech Stack

• Education: Master's degree or PhD (submitted within the last one year) in a life sciences field.
• Experience:
• 0-4 years of confirmed experience (with a Master's degree).
• A PhD with a strong focus on protein biology, protein design, protein purification, antibody or protein conjugations, molecular biology, immunology, biotechnology, or biochemistry.
• Skills & Knowledge:
• Strong theoretical and working knowledge in protein expression, protein purification, and antibody purification.
• Experience working with different expression systems, inclusion bodies, and re-folding.
• Hands-on experience performing protein purification using affinity, ion-exchange, and size exclusion chromatography.
• Experience in automated purification method development in AKTA, NGC, and liquid handler.
• Characterization of proteins using SDS-PAGE, SEC-HPLC.
• Validating proteins in immunoassays such as ELISA, western blot, and IF.
• Experience or familiarity with protein engineering, rational design of mutants, and molecular biology.
• Experience with structural biology and protein modeling and visualization tools such as Pymol, Schrodinger, Discovery Studio, or similar programs.
• Project or work experience in support of relevant skills (e.g., publications, project reports, thesis work).
• Proficiency in MS Office applications (Word, Powerpoint, Excel).
• Strong statistical knowledge and familiarity with statistical software such as Prism.
• Personal Attributes:
• Self-motivated and a self-starter.
• Excellent at learning and applying new concepts for process or product improvements.
• Excellent oral and written communication skills.
• Ability to work with diverse colleagues.