Scientist I, Bioanalytical

About the Role

Nurix Therapeutics is seeking a motivated Scientist I, Bioanalytical to join our Bioanalytical team and contribute to drug discovery programs. This role involves supporting in vivo and in vitro studies with bioanalytical efforts, focusing on generating high-quality bioanalytical data to guide decisions.

Key Responsibilities

• Provide bioanalytical support for in vivo PK, PK/PD, efficacy studies, non-GLP toxicology, and in vitro studies.
• Conduct bioanalytical method development and qualification for drug, metabolite, and biomarker analysis.
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples and execute sample analysis.
• Independently operate, troubleshoot, and maintain LC-MS/MS and analytical equipment.
• Quantitate drug candidates and their metabolites, and endogenous biomarkers in biological matrices (e.g., blood, plasma, tissues, tumor, CSF).
• Participate in multidisciplinary project teams and partner closely with pharmacology, chemistry, and biology teams to understand bioanalytical needs for PK support.
• Maintain accurate and detailed laboratory notebooks.

Requirements & Tech Stack

• LC-MS/MS
• Sciex platforms and software
• H/UPLC (Preferred)

Qualifications

• BS or equivalent with 10 or more years’ relevant experience, OR
• MS with 6 or more years’ relevant experience, OR
• PhD with up to 4 years’ relevant experience working in a discovery setting using quantitative LC-MS/MS within a pharmaceutical or biotechnology company.
• Demonstrated experience in small molecule biomarkers and drug candidate bioanalytical assay development/sample quantitative analysis in complex biological matrices using LC-MS/MS.
• Proven experience running and troubleshooting LC-MS/MS-based quantitative workflows on Sciex platforms and software.
• Excellent written, verbal communications, and interpersonal skills to collaborate with internal and external partners in a matrix environment.
• Ability to work in a fast-paced, collaborative environment and manage multiple priorities.
• Ability to think and plan strategically.
• Excellent interpersonal skills and ability to work in a team environment.

Preferred Qualifications

• Experience in targeted protein degradation or heterobifunctional degrader platforms.
• Extensive experience with H/UPLC and mass spectrometry.
• Extensive experience with sample analysis to support PK, PK/PD, efficacy, distribution, metabolism, and non-GLP toxicology studies.
• Extensive experience in developing and implementing quantitative LC-MS/MS based assays for small molecules in complex biological matrices.
• Excellent oral and written communication skills.
• Experience reviewing result files and reports from bioanalytical contract research organizations.
• Experience with maintaining detailed, up-to-date lab notebooks and technical documentation.

Location: Onsite – Brisbane, CA

Salary Range: $141,500 - $175,600