Upstream Process Development Scientist

About the Role

Eurofins PSS is seeking an Upstream Process Development Scientist to support a client's upstream process development activities for sterile, injectable lentiviral vector (LVV)-based gene therapy products. This role will focus on the execution and optimization of LVV production protocols, maintenance of mammalian suspension cell culture systems, process robustness, and yield-improvement studies. You will partner closely with cross-functional teams across CMC project teams to support upstream operations.

Key Responsibilities

• Execute LVV production protocols using shake flasks and benchtop bioreactors for process development and characterization studies.
• Support routine maintenance of mammalian suspension cell cultures, applying strong aseptic technique and sterile workflow practices.
• Collaborate with cross-functional teams for analytical testing, material exchange, technical observations, and project timeline alignment.
• Maintain lab stocks, supplies, and equipment for the upstream team.
• Document process data in an electronic lab notebook and shared databases.
• Communicate key observations in team meetings.

Requirements & Tech Stack

• Mammalian suspension cell culture operations, including routine culture maintenance and shake flask seed train expansion.
• Strong aseptic technique and hands-on experience within a biosafety cabinet (BSC).
• Buffer and media preparation for cell culture operations.
• Documenting process results in electronic lab notebooks.
• Communicating experimental observations to management and cross-functional teams.
• Prioritization and multi-tasking abilities.
• Strong organizational skills.
• Self-motivation and a positive attitude.
• Communication skills to clearly present experimental results and observations.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Qualifications

• B.S. in Biology, Biochemistry, Biological Engineering, or a related field with at least 1 year of relevant industry experience.

OR

• M.S. in Biology, Biochemistry, Biological Engineering, or a related field with at least 6 months of relevant industry experience.

Preferred Qualifications

• Previous experience with viral vector, cell therapy, gene therapy, or related biologics process development.
• Hands-on experience operating and maintaining laboratory equipment, including shake flasks, benchtop bioreactor systems, peristaltic pumps, and tube welders.
• Experience performing cell banking activities.
• Familiar with gene delivery techniques such as transient transfection.

Additional Information

• This is a full-time, permanent position.
• Work schedule: Monday-Friday, 8am-5pm, with occasional weekend/holiday work and periodic work outside of standard hours.
• Candidates located within commutable distance to Boston, MA are encouraged to apply.
• Compensation: $32.00-$36.00 per hour based on education and relatable industry experience.