Scientist III, Synthetics Laboratory

About the Role

The incumbent will be responsible for the synthesis and delivery of USP Reference Standard candidate materials and API impurities through the design and development of safe, efficient, and cost-effective synthetic routes. This role involves conducting comprehensive literature searches using scientific databases, planning synthetic strategies, and executing the synthesis of target molecules from milligram to multigram/kilogram scale. The candidate will be expected to ensure the timely completion of assigned projects, prepare technical reports, effectively communicate project progress to stakeholders, and collaborate closely with team members to achieve project objectives. Adherence to Quality Management System (QMS) requirements and laboratory safety policies is also required.

Key Responsibilities

• Carry out literature search related to assigned projects using various scientific databases.
• Design synthetic routes for target small molecules.
• Prepare project proposals with tentative cost estimates.
• Perform synthesis & isolation of API impurities and reference standards candidate materials.
• Procure key raw materials and reagents required for the project.
• Perform reactions in small as well as large scale in the lab for the synthesis of target compounds.
• Purify compounds through techniques such as crystallization, column chromatography, and advanced flash purification systems.
• Troubleshoot synthesis and purification issues independently.
• Contribute effectively towards more challenging and complex projects through innovative synthetic methodologies.
• Ensure the availability of chemicals and equipment required for the projects and forward purchase requisitions.
• Interpret analytical data of synthesized compounds by IR, NMR, Mass Spectra, Elemental analysis, etc.
• Contribute to organizational initiatives.
• Produce quality materials as per customer requirement.
• Package synthesized compounds.
• Plan, execute, and complete projects as per the timelines.
• Document all experiments conducted as per QMS guidelines.
• Responsible for the preparation of SOPs, Protocols, reports, etc. as per the need.
• Responsible for ensuring the calibration of equipment as per the schedule.
• Periodically check assigned equipment to ensure its working condition.
• Responsible for preparing, executing, and completing IQ/OQ/PQ of new instruments as assigned.
• Work on any other assigned tasks/lab management activities.
• Adhere to lab safety norms and strictly follow them.
• Communicate within the team and cross-functional teams.
• Learn and practice USP’s Equity Equals Excellence (EEE).

Requirements & Tech Stack

• Ph.D (Full Time) in Synthetic Organic Chemistry from a reputed group with 0-3 years of post doctoral and/or industrial research experience in API Process R&D/CDMO/CRO.

OR

• M.Sc (Organic Chemistry) from a reputed university with minimum 6-8 years of industrial experience in API Process R&D/CDMO/CRO.

Qualifications

• Strong background in synthetic organic chemistry.
• Interpretation of spectral data of compounds based on IR, NMR, HPLC, Mass, Elemental analysis and other analyses.
• Ability to independently search literature and design, optimize, and develop synthetic processes for any given target molecules/APIs.
• Hands-on experience in process development of diverse chemical entities on lab scale.
• Proven ability for adoption of QMS and documentation procedures.
• Adherence to lab safety guidelines.
• Excellent troubleshooting skills in synthesis and purification of target compounds.
• Good verbal and written communication skills.
• Good organizational, communication, and interpersonal skills.
• Demonstrated ability as a team player.

Additional Desired Preferences

• Extensive knowledge of a wide range of organic reactions and hands-on experience in handling various sensitive chemicals/reagents.
• Track record of patents/publications in synthetic organic chemistry/process development.
• Exposure to GMP/GLP environment and documentation procedures.
• Good practical, documentation & presentation skills.
• Attention to detail, strategic thinking, and problem-solving skills.
• Demonstrated ability to work both independently and as a member of a team with a passion for quality.